We list out the special functions that Vitess handles without delegating to MySQL here.
Please note that the Vitess community determined a workaround if you want to use a JPA like Hibernate/Eclipselink to talk to Vitess.
Rather than using GenerationType.IDENTITY you can use Eclipselink QuerySequence to define a query directly to Vitess Sequences tables. This not only prevents SELECT LAST_INSERT_ID() call but also can reduce the number of database trips since the application could request a bunch of IDs from Vitess. Potentially around 1000, so this setup will make only one call per 1000 inserts.